Brand Name: Actiprofen (CAN), Advil, Advil Liqui-Gels, Advil Migraine, Alti-Ibuprofen (CAN), Apo-Ibuprofen (CAN), Children's Advil, Children's Motrin, Genpril, Haltran, Infants' Motrin, Junior Strength Advil, Junior Strength Motrin, Menadol, Midol, Midol Maximum Strength Cramp, Motrin, Motrin IB, Motrin Migraine Pain, Novo-Profen (CAN), Nuprin, PediaCare Fever, Pediatric Advil Drops
Pregnancy Category B
Drug classes: Nonsteroidal anti-inflammatory drug (NSAID), Analgesic (non-narcotic),
Propionic acid derivative,
Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known
· Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
· Relief of mild to moderate pain
· Treatment of primary dysmenorrhea
· Fever reduction
· Contraindicated with allergy to ibuprofen, salicylates, or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps); CV dysfunction, hypertension; peptic ulceration, GI bleeding; pregnancy; lactation.
Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthalmologic effects
Rash, pruritus, sweating, dry mucous membranes, stomatitis
Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence, GI bleeding
Dysuria, renal impairment, menorrhagia
Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression
Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis
Peripheral edema, anaphylactoid reactions to anaphylactic shock
· Increased toxic effects of lithium with ibuprofen
· Decreased diuretic effect with loop diuretics: bumetanide, furosemide, ethacrynic acid
· Potential decrease in antihypertensive effect of beta-adrenergic blocking agents
· Administer drug with food or after meals if GI upset occurs.
· Arrange for periodic ophthalmologic examination during long-term therapy.
· Discontinue drug if eye changes, symptoms of liver dysfunction, renal impairment occur.
· Institute emergency procedures if overdose occurs: gastric lavage, induction of emesis, supportive therapy.