Brand Name: Apo-Cimetidine (CAN), Gen-Cimetidine (CAN), Novo-Cimetine (CAN), Nu-Cimet (CAN), Peptol (CAN), Tagamet, Tagamet HB, Tagamet HB Suspension
Pregnancy Category B
Drug class: Histamine2 (H2) antagonist
Inhibits the action of histamine at the histamine2 (H2) receptors of the stomach, inhibiting gastric acid secretion and reducing total pepsin output.
· Short-term treatment of active duodenal ulcer
· Short-term treatment of benign gastric ulcer
· Treatment of pathologic hypersecretory conditions (Zollinger-Ellison syndrome)
· Prophylaxis of stress-induced ulcers and acute upper GI bleeding in critical patients
· Treatment of erosive gastroesophageal reflux
· Relief of symptoms of heartburn, acid indigestion, sour stomach (OTC use)
· Allergy to cimetidine, impaired renal or hepatic function, lactation.
Dizziness, somnolence, headache, confusion, hallucinations, peripheral neuropathy; symptoms of brain stem dysfunction (dysarthria, ataxia, diplopia), Cardiac arrhythmias, cardiac arrest, hypotension (IV use), Diarrhea, Increases in plasma creatinine, serum transaminase, Impotence (reversible), gynecomastia (in long-term treatment), rash, vasculitis, pain at IM injection site
· Increased risk of decreased white blood cell counts with antimetabolites, alkylating agents, other drugs known to cause neutropenia
· Increased serum levels and risk of toxicity of warfarin-type anticoagulants, phenytoin, beta-adrenergic blocking agents, alcohol, quinidine, lidocaine, theophylline, chloroquine, certain benzodiazepines (alprazolam, chlordiazepoxide, diazepam, flurazepam, triazolam), nifedipine, pentoxifylline, tricyclic antidepressants, procainamide, carbamazepine when taken with cimetidine
· Give drug with meals and at hs.
· Decrease doses in renal and liver dysfunction.
· Administer IM dose undiluted deep into large muscle group.
· Arrange for regular followup, including blood tests to evaluate effects.