Brand Name: Diflucan
Pregnancy Category C
Drug class: Antifungal
Binds to sterols in the fungal cell membrane, changing membrane permeability; fungicidal or fungistatic depending on concentration and organism.
· Treatment of oropharyngeal, esophageal, and vaginal candidiasis
· Treatment of cryptococcal meningitis
· Treatment of systemic fungal infections
· Prophylaxis to decrease incidence of candidiasis in bone marrow transplants
· Contraindicated with hypersensitivity to fluconazole, lactation.
· CNS: Headache
· GI: Nausea, vomiting, diarrhea, abdominal pain
· Other: Rash
· Increased serum levels and therefore therapeutic and toxic effects of cyclosporine, phenytoin, benzodiazepines, oral hypoglycemics, warfarin anticoagulants, zidovudine
· Decreased serum levels with rifampin, theophylline, TCAs, losartan
· Culture infection prior to therapy; begin treatment before lab results are returned.
· Decrease dosage in cases of renal failure.
· Infuse IV only; not intended for IM or SC use.
· Do not add supplement medication to fluconazole.
· Administer through sterile equipment at a maximum rate of 200 mg/hr given as a continuous infusion.
· Monitor renal function tests weekly, discontinue or decrease dosage of drug at any sign of increased renal toxicity.