07/04/2009 16:18


Brand Name: Actiprofen (CAN), Advil, Advil Liqui-Gels, Advil Migraine, Alti-Ibuprofen (CAN), Apo-Ibuprofen (CAN), Children's Advil, Children's Motrin, Genpril, Haltran, Infants' Motrin, Junior Strength Advil, Junior Strength Motrin, Menadol, Midol, Midol Maximum Strength Cramp, Motrin, Motrin IB, Motrin Migraine Pain, Novo-Profen (CAN), Nuprin, PediaCare Fever, Pediatric Advil Drops


Pregnancy Category B

Drug classes: Nonsteroidal anti-inflammatory drug (NSAID), Analgesic (non-narcotic),

Propionic acid derivative,


Therapeutic actions

Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known




· Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis

· Relief of mild to moderate pain

· Treatment of primary dysmenorrhea

· Fever reduction




· Contraindicated with allergy to ibuprofen, salicylates, or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps); CV dysfunction, hypertension; peptic ulceration, GI bleeding; pregnancy; lactation.



Adverse effects

Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthalmologic effects

Rash, pruritus, sweating, dry mucous membranes, stomatitis

Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence, GI bleeding

Dysuria, renal impairment, menorrhagia

Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression

Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis

Peripheral edema, anaphylactoid reactions to anaphylactic shock


· Increased toxic effects of lithium with ibuprofen

· Decreased diuretic effect with loop diuretics: bumetanide, furosemide, ethacrynic acid

· Potential decrease in antihypertensive effect of beta-adrenergic blocking agents



Nursing considerations

· Administer drug with food or after meals if GI upset occurs.

· Arrange for periodic ophthalmologic examination during long-term therapy.

· Discontinue drug if eye changes, symptoms of liver dysfunction, renal impairment occur.

· Institute emergency procedures if overdose occurs: gastric lavage, induction of emesis, supportive therapy.