Benazepril Hydrochloride

Benazepril hydrochloride

Brand Name: Lotensin

Pregnancy Category C (first trimester), Pregnancy Category D (second, third trimesters)

Drug classes: Antihypertensive, Angiotensin-converting enzyme (ACE) inhibitor

 

Therapeutic actions

Blocks ACE from converting angiotensin I to angiotensin II, a potent vasoconstrictor, leading to decreased BP, decreased aldosterone secretion, a small increase in serum potassium levels, and sodium and fluid loss; increased prostaglandin synthesis also may be involved in the antihypertensive action.

 

Indications

· Treatment of hypertension alone or in combination with thiazide-type diuretics

 

Contraindications

· Contraindicated with allergy to benazepril or other ACE inhibitors.

 

Adverse effects

Angina pectoris, hypotension in salt/volume depleted patients, palpitations, rash, pruritus, diaphoresis, flushing, Nausea, abdominal pain, vomiting, constipation, Cough, asthma, bronchitis, dyspnea, sinusitis, Angioedema, impotence, decreased libido, asthenia, myalgia, arthralgia

Drug Interactions

· Increased risk of hypersensitivity reactions with allopurinal

· Increased coughing with capsaicin

· Decreased antihypertensive effects with indomethacin

· Increased lithium levels and neurotoxicity may occur if combined

· Increased risk of hyperkalemia with potassium-sparing diuretics or potassium supplements

 

Nursing considerations

· Alert surgeon: Note use of benazepril on patient's chart; the angiotensin II formation subsequent to compensatory renin release during surgery will be blocked; hypotension may be reversed with volume expansion.

· Monitor patient for possible fall in BP secondary to reduction in fluid volume (excessive perspiration and dehydration, vomiting, diarrhea) because excessive hypotension may occur.

· Reduce dosage in patients with impaired renal function.