Brand Name: Biaxin, Biaxin XL
Pregnancy Category B
Drug class: Macrolide antibiotic
Inhibits protein synthesis in susceptible bacteria, causing cell death.
· Treatment of upper respiratory infections caused by S. pyogenes, S. pneumoniae
· Treatment of lower respiratory infections caused by Mycoplasma pneumoniae, S. pneumoniae, H. influenzae, M. catarrhalis
· Treatment of skin and structure infections caused by S. aureus, S. pyogenes
· Treatment of disseminated mycobacterial infections due to M. avium and M. intracellular
· Treatment of active duodenal ulcer with H. pylori in combination with proton pump inhibitor
· Treatment of acute otitis media, acute maxillary sinusitis due to H. influenzae, M. cararrhalis, S. pneumoniae
· Treatment of mild to moderate community-acquired pneumonia in adults (ER tablets)
· Contraindicated with hypersensitivity to clarithromycin, erythromycin, or any macrolide antibiotic.
Dizziness, headache, vertigo, somnolence, fatigue, Diarrhea, abdominal pain, nausea, dyspepsia, flatulence, vomiting, melena, pseudomembranous colitis, Superinfections, increased PT, decreased WBC
· Increased serum levels and effects of carbamazepine, theophylline, lovastatin, phenytoin
Interaction with Food:
· Food decreases the rate of absorption of clarithromycin but does not alter effectiveness
· Decreased metabolism and risk of toxic effects if combined with grapefruit juice; avoid this combination.
· Culture infection before therapy.
· Do not cut or crush, and ensure that patient does not chew ER tablets.
· Monitor patient for anticipated response.
· Administer without regard to meals; administer with food if GI effects occur.